If you love creamy, cheesy comfort food that warms your soul, this Chicken Bubble Biscuit Bake Casserole is the perfect pick. It’s a hearty, crowd-pleasing dish filled with tender chicken, rich sauce, melted cheese, and fluffy biscuit pieces that bake into golden, buttery “bubbles.” Whether it’s a cozy Sunday meal or a quick weeknight dinner, this casserole delivers pure satisfaction in every bite.
What makes this recipe so special is how easy and versatile it is. You can use leftover rotisserie chicken, cooked breasts, or thighs—whatever you have on hand. As it bakes, the biscuit dough transforms into soft, buttery pillows surrounded by a creamy, cheesy filling that’s absolutely irresistible.
Ingredients
Here’s everything you need to make this comforting Chicken Bubble Biscuit Bake Casserole that serves 4 to 6 people:
| Ingredient | Quantity |
|---|---|
| Cooked chicken, diced or shredded (rotisserie works perfectly) | 2 cups |
| Cream of chicken soup | 1 can (10.5 oz) |
| Sour cream | ½ cup |
| Milk | ½ cup |
| Shredded cheddar cheese (divided) | 1½ cups |
| Refrigerated biscuit dough, cut into quarters | 1 can (16 oz) |
| Frozen mixed vegetables (peas, carrots, and corn) | 1 cup |
| Garlic powder | ½ teaspoon |
| Onion powder | ½ teaspoon |
| Dried thyme or Italian seasoning | ½ teaspoon |
| Salt and pepper | To taste |
| Butter, melted | 2 tablespoons |
| Optional garnish: chopped parsley or green onions | — |
Directions
Step 1: Get your oven ready
Preheat your oven to 350°F (175°C). Lightly grease a 9×13-inch or deep casserole dish with butter or nonstick spray to make sure nothing sticks and cleanup is easy later.
Step 2: Mix up the creamy chicken base
In a large bowl, whisk together the cream of chicken soup, sour cream, and milk until smooth. Season with garlic powder, onion powder, thyme, salt, and pepper. Then fold in the cooked chicken, frozen vegetables, and 1 cup of cheddar cheese until evenly coated with the creamy mixture.
Step 3: Add the biscuit “bubbles”
Cut the refrigerated biscuit dough into quarters. Gently stir the pieces into your chicken mixture—just enough to coat them without squishing. These little dough bites will puff up beautifully as they bake, forming those signature golden, bubbly layers.
Step 4: Build your casserole
Spread the mixture evenly into your greased baking dish. Sprinkle the remaining ½ cup of cheese on top, then drizzle melted butter over everything for extra richness and flavor.
Step 5: Bake to golden perfection
Bake for 30–40 minutes, or until the biscuits are fully cooked and the top is golden brown. If the top starts browning too quickly, loosely cover it with foil halfway through baking.
Step 6: Cool and serve
Allow the casserole to rest for 5–10 minutes after baking. This helps the sauce thicken and the biscuits set perfectly. Finish with chopped parsley or green onions for a fresh pop of color before serving.
Tips for Best Results
- Use pre-cooked chicken: Rotisserie chicken works best for a quick, flavorful base.
- Be gentle with the biscuits: Avoid overmixing to keep them fluffy and light.
- Check for doneness: Insert a toothpick into the center—if it comes out clean, the biscuits are done.
- Add crunch: For a crispy twist, sprinkle crushed Ritz crackers or French-fried onions on top before baking.
- Make ahead: Assemble the casserole up to 24 hours in advance, refrigerate, then bake when ready for a stress-free meal.
This easy Chicken Bubble Biscuit Bake Casserole is the perfect mix of creamy, cheesy, and cozy—a dish guaranteed to become a new family favorite.
