This Chicken Biscuit Casserole Is So Good, It Disappears Fast (Family Dinner Favorite!)

Chicken Bubble Biscuit Bake Casserole is one of those cozy, oven-baked meals that instantly feels like home. It’s creamy, filling, and made with simple pantry staples that come together in one comforting dish. Juicy shredded chicken, soft biscuit pieces, and a rich, savory sauce bake into a bubbly casserole that’s perfect for busy weeknights, casual gatherings, or stress-free meal prep. If you’re looking for an easy comfort food recipe that delivers big flavor without complicated steps, this one checks every box.

Ingredients

To serve about 6 people, you’ll need:

For the Base

Ingredient Quantity
Cooked, shredded chicken (rotisserie works well) 2 cups
Cream of chicken soup 1 can (10.5 oz)
Sour cream or Greek yogurt ½ cup
Shredded cheddar cheese (or blend) 1 cup
Milk ¼ cup
Garlic powder 1 tsp
Onion powder ½ tsp
Black pepper ½ tsp
Salt To taste

For the Biscuits

Ingredient Quantity
Refrigerated buttermilk biscuit dough 1 can (16 oz, 8 biscuits)
Melted butter 2 tbsp
Fresh parsley or chives (optional) For garnish

Instructions

Step 1: Preheat and Prepare
Set your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish with butter or non-stick spray to keep everything from sticking and make cleanup easier.

Step 2: Make the Creamy Chicken Mixture
In a large bowl, whisk together the cream of chicken soup, sour cream, milk, garlic powder, onion powder, salt, and black pepper until smooth. Add the shredded chicken and ½ cup of the cheese, stirring until the chicken is fully coated in the creamy sauce.

Step 3: Prep the Biscuits
Cut each biscuit into quarters. These smaller pieces create the signature “bubble” texture and help the dough bake evenly throughout the casserole.

Step 4: Combine Everything
Gently fold the biscuit pieces into the chicken mixture until they’re well coated. Mix just until combined to keep the biscuit dough intact.

Step 5: Assemble the Casserole
Transfer the mixture into the prepared baking dish and spread it out evenly. Sprinkle the remaining cheese over the top to create a rich, golden finish.

Step 6: Bake Until Golden
Bake for 30–35 minutes, or until the biscuits are puffed, cooked through, and the cheese is melted and bubbly. Insert a toothpick into the center to check doneness—it should come out clean.

Step 7: Finish and Serve
Remove the casserole from the oven and brush the top lightly with melted butter for extra flavor and shine. Garnish with chopped parsley or chives if desired. Let it rest for about 5 minutes before serving so the sauce thickens slightly and slices cleanly.

This easy chicken biscuit casserole is creamy, satisfying, and guaranteed to be a repeat request at the dinner table.